2026-09-062 min
TP508 in Fracture Repair: What the Mouse Model Showed
A study-level review of TP508 in an 80-mouse high-energy femoral fracture model, including stiffness, callus and translation limits.
Evidence Review DeskRead →
RPE / SOURCE INDEX
Evidence before peptide claims.
See what is human, preclinical, regulated, prohibited, or still unknown.
- Evidence reviews
- 113
- Compound profiles
- 13
- Editorial desks
- 3
01 / LATEST REVIEWS
New entries in the evidence file.
Each review distinguishes direct human findings from mechanisms, animal models, and regulatory records.
2026-09-033 min
Why Positive Phase II Results Do Not Establish Approval
Avotermin as a case study in why promising phase II data, a phase III trial and regulatory approval are separate milestones.
Regulatory Research DeskRead →
2026-08-312 min
TGF-Beta 3 and Scar Biology: Mechanism vs Clinical Proof
How TGF-β3 influenced the avotermin scar hypothesis, and why collagen architecture and signaling do not replace clinical outcomes.
Evidence Review DeskRead →
2026-08-282 min
Avotermin After Varicose Vein Surgery: Trial Findings
What the paired phase II avotermin study after bilateral varicose-vein surgery measured, reported and left unresolved.
Evidence Review DeskRead →
2026-08-252 min
Avotermin After Scar Revision Surgery: Phase II Review
A study-level review of the 60-person within-patient avotermin trial after complete or staged scar revision surgery.
Evidence Review DeskRead →
2026-08-222 min
Avotermin for Scar Reduction: Phase I/II Evidence
What three early avotermin studies found about scar appearance, and how paired wounds, visual scores and multiple regimens limit interpretation.
Evidence Review DeskRead →
Nine profiles. Exact identities. Explicit gaps.
Profiles cover proposed mechanisms, preclinical and human evidence, safety, FDA context, WADA status, and research gaps.
Browse the full index
Tissue Repair Peptides
TP508 (Chrysalin/Rusalatide) Tissue Repair Evidence Profile
TP508, also called Chrysalin or rusalatide acetate, is a synthetic 23-amino-acid thrombin-related peptide studied in wound and bone repair. Early ulcer findings and animal mechanisms must be weighed against a 274-person distal-radius trial terminated after no benefit versus placebo was demonstrated.
Preclinical EvidenceHuman Clinical EvidenceWound HealingBone Repair
Open dossier
Tissue Repair Peptides
PXL01 Tendon Repair and Post-Surgical Adhesion Evidence Profile
PXL01 is a synthetic human lactoferrin-derived peptide studied as part of a sodium hyaluronate formulation applied during flexor tendon repair surgery. A 138-patient randomized trial reported selected functional signals, mainly in per-protocol analyses, but did not establish an approved tendon-repair medicine.
Preclinical EvidenceHuman Clinical EvidenceTendon ResearchPost-Surgical Adhesion
Open dossier
Tissue Repair Peptides
BPC-157 Evidence, Safety and Regulatory Profile
BPC-157 is a synthetic 15-amino-acid peptide promoted online for injury recovery. Most claims about tendon, ligament, muscle, nerve, and gastrointestinal repair come from animal or laboratory work. Human evidence remains limited and does not establish broad recovery benefits.
Preclinical EvidenceHuman Clinical EvidenceFDA Safety ReviewTendon ResearchSports Regulation
Open dossier
Do not flatten different evidence into one claim.
The same question can contain five distinct evidence objects.
Read the full method- 01
Identify the material
Sequence, fragment, formulation, route, and finished product must match.
- 02
Locate the evidence level
Human outcomes carry different weight from animal or cell signals.
- 03
Read the uncertainty
Missing safety data and small studies are findings, not blank space.
- 04
Separate rule systems
FDA status, compounding policy, and WADA rules answer different questions.
04 / TOPIC ROUTES
Enter through a research question.
Follow evidence type, safety, tissue context, regulation, or sports rules without turning tags into thin claims.
Evidence Review
Source-led reviews of the quality, scope, and limitations of peptide evidence.
70→Human StudiesClinical studies, trial registrations, and human exposure evidence.
51→Preclinical ResearchAnimal, cell, and mechanistic research with clear translation limits.
52→Regulatory StatusFDA, compounding, approved-label, and regulatory-source reviews.
36→SafetyKnown safety findings, evidence gaps, product-quality concerns, and unresolved risks.
44→Wound HealingEvidence concerning skin, chronic wounds, and tissue-repair research.
29→Tendon and LigamentResearch on tendon, ligament, and connective-tissue recovery.
8→Muscle RecoveryPreclinical and human evidence related to muscle injury and recovery.
1→05 / ACCOUNTABILITY
Editorial roles, clearly named.
Team and desk bylines describe responsibility without inventing clinical credentials.
Meet the editorial desks